Liang Kong Selected Research

osthol (osthole)

9/2021	Multifunctional osthole liposomes and brain targeting functionality with potential applications in a mouse model of Alzheimer's disease.
3/2021	Osthole ameliorates cognitive impairments via augmenting neuronal population in APP / PS1 transgenic mice.
1/2020	Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer's Disease-Related Pathology in APP/PS-1 Mice.
4/2019	Osthole alleviates inflammation by down-regulating NF-κB signaling pathway in traumatic brain injury.
1/2019	Osthole decreases tau protein phosphorylation via PI3K/AKT/GSK-3β signaling pathway in Alzheimer's disease.
1/2018	[Osthole suppresses amyloid precursor protein expression by up-regulating miRNA-101a-3p in Alzheimer's disease cell model].
1/2018	Osthole promotes endogenous neural stem cell proliferation and improved neurological function through Notch signaling pathway in mice acute mechanical brain injury.
9/2016	Neuroprotective Effect of Osthole on Neuron Synapses in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9.
1/2016	Osthole decreases beta amyloid levels through up-regulation of miR-107 in Alzheimer's disease.
12/2015	Osthole promotes neuronal differentiation and inhibits apoptosis via Wnt/β-catenin signaling in an Alzheimer's disease model.

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Liang Kong Research Topics

Disease

15	Alzheimer Disease (Alzheimer's Disease) 12/2022 - 01/2015
15	Neoplasms (Cancer) 11/2021 - 02/2007
5	Neoplasm Metastasis (Metastasis) 06/2021 - 12/2019
5	Brain Injuries (Brain Injury) 01/2021 - 09/2015
5	Infections 10/2018 - 01/2012
3	Neuroinflammatory Diseases 12/2022 - 11/2019
3	Osteoporosis 01/2022 - 07/2011
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 06/2021 - 12/2019
3	Cognitive Dysfunction 03/2021 - 01/2015
3	Breast Neoplasms (Breast Cancer) 06/2020 - 01/2020
3	Inflammation (Inflammations) 04/2019 - 09/2015
2	Dementia (Dementias) 10/2021 - 09/2020
2	Porcine Reproductive and Respiratory Syndrome (PRRS) 10/2021 - 01/2020
2	Pain (Aches) 06/2021 - 11/2016
2	Ischemic Stroke 01/2020 - 09/2015
2	Stroke (Strokes) 01/2020 - 04/2014
2	Stab Wounds (Stab Wound) 04/2019 - 09/2015
2	Wounds and Injuries (Trauma) 09/2015 - 09/2012
2	Adenoid Cystic Carcinoma (Cylindroma) 04/2012 - 01/2012
2	Bone Resorption 01/2012 - 01/2010
1	Rheumatoid Arthritis 01/2022
1	Psychomotor Agitation (Akathisia) 01/2022
1	Ovarian Neoplasms (Ovarian Cancer) 11/2021
1	Hematoma 10/2021
1	Compression Fractures (Compression Fracture) 06/2021
1	Stomach Neoplasms (Stomach Cancer) 06/2021
1	Reperfusion Injury 03/2021
1	Colles' Fracture 03/2020
1	Cerebral Infarction 03/2020
1	Sepsis (Septicemia) 01/2020
1	Lung Injury 01/2020

Drug/Important Bio-Agent (IBA)

13	Liposomes (Liposome)IBA 12/2022 - 12/2019
12	Proteins (Proteins, Gene)FDA Link 11/2021 - 01/2012
12	osthol (osthole)IBA 09/2021 - 01/2015
4	Pharmaceutical PreparationsIBA 10/2021 - 01/2020
4	Epirubicin (Ellence)FDA LinkGeneric 06/2021 - 12/2019
4	Phosphotransferases (Kinase)IBA 03/2020 - 01/2012
4	Amyloid (Amyloid Fibrils)IBA 01/2018 - 12/2015
4	Peptides (Polypeptides)IBA 09/2016 - 02/2007
3	schizandrin BIBA 11/2021 - 04/2020
3	Therapeutic UsesIBA 04/2020 - 02/2016
3	Neuroprotective AgentsIBA 09/2016 - 04/2014
2	tanshinoneIBA 12/2022 - 03/2021
2	Pattern Recognition ReceptorsIBA 10/2021 - 01/2020
2	coumarinIBA 09/2021 - 01/2020
2	Bone Cements (Bone Glue)IBA 06/2021 - 01/2012
2	dioscinIBA 06/2020 - 02/2020
2	Daunorubicin (Cerubidine)FDA LinkGeneric 06/2020 - 01/2020
2	Caspase 3 (Caspase-3)IBA 03/2020 - 01/2016
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2020 - 11/2019
2	Interleukin-6 (Interleukin 6)IBA 01/2020 - 01/2016
2	Biological ProductsIBA 01/2020 - 01/2012
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 02/2007
2	CytokinesIBA 01/2020 - 04/2019
2	panaxadiolIBA 05/2019 - 03/2019
2	Histones (Histone)IBA 10/2018 - 04/2017
2	Amyloid beta-PeptidesIBA 01/2016 - 01/2015
2	ocotillolIBA 01/2014 - 01/2013
2	Basigin (Extracellular Matrix Metalloproteinase Inducer (EMMPRIN))IBA 04/2012 - 01/2012
2	Glycoproteins (Glycoprotein)IBA 04/2012 - 01/2012
2	Matrix Metalloproteinases (MMPs)IBA 04/2012 - 01/2012
1	icariinIBA 12/2022
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2022
1	triptolideIBA 01/2022
1	Small Interfering RNA (siRNA)IBA 01/2022
1	Cell-Penetrating PeptidesIBA 11/2021
1	Paclitaxel (Taxol)FDA LinkGeneric 11/2021
1	ChemokinesIBA 10/2021
1	Interleukin-8 (Interleukin 8)IBA 10/2021
1	tetrandrineIBA 06/2021
1	gingerolIBA 01/2021
1	Scopolamine (Hyoscine)FDA Link 09/2020
1	Cadherins (E-Cadherin)IBA 04/2020
1	VimentinIBA 04/2020
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 04/2020
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2020
1	buyang huanwuIBA 03/2020
1	Alkaline PhosphataseIBA 03/2020
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 03/2020
1	RNA (Ribonucleic Acid)IBA 03/2020
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 03/2020
1	TensinsIBA 03/2020
1	Phosphatidylinositols (Phosphatidylinositol)IBA 03/2020
1	Antineoplastic Agents (Antineoplastics)IBA 02/2020
1	Deoxyglucose (2 Deoxy D glucose)IBA 01/2020
1	FructoseIBA 01/2020
1	EnzymesIBA 01/2020
1	Emodin (Archin)IBA 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	Oxygen (Dioxygen)IBA 01/2020

Therapy/Procedure

7	Therapeutics 01/2022 - 05/2003
5	Drug Therapy (Chemotherapy) 11/2021 - 02/2020
3	Aftercare (After-Treatment) 01/2022 - 04/2010
1	Ovariectomy (Oophorectomy) 01/2022
1	Kyphoplasty 06/2021
1	Chinese Traditional Medicine (Traditional Chinese Medicine) 09/2020
1	Splints (Splint) 03/2020
1	Ligation 01/2020
1	Oral Medicine 01/2020
1	Punctures 01/2020